RNA location and modeling of a WD40 repeat domain within the vault

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چکیده

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RNA location and modeling of a WD40 repeat domain within the vault.

The vault complex is a ubiquitous 13-MDa ribonucleoprotein assembly, composed of three proteins (TEP1, 240 kDa; VPARP, 193 kDa; and MVP, 100 kDa) that are highly conserved in eukaryotes and an untranslated RNA (vRNA). The vault has been shown to affect multidrug resistance in cancer cells, and one particular component, MVP, is thought to play a role in the transport of drug from the nucleus. To...

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ژورنال

عنوان ژورنال: RNA

سال: 2000

ISSN: 1355-8382

DOI: 10.1017/s1355838200000157